%0 Journal Article
%T Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia.
%A Cirillo R
%A Duperrier S
%A Parekh P
%A Millot M
%A Li Q
%A Thiolat ML
%A Morelli M
%A Xie J
%A Le Bars D
%A Redouté J
%A Bezard E
%A Sgambato V
%J J Parkinsons Dis
%V 14
%N 2
%D 2024
%M 38339940
%F 5.52
%R 10.3233/JPD-230331
%X Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson's disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4R might offer a therapeutic target for dampening PD's symptoms.