%0 Journal Article
%T Should non-invasive prenatal testing be recommended for patients who achieve pregnancy with PGT?
%A Liang Y
%A Li M
%A Fei J
%A Chen Z
%J BMC Pregnancy Childbirth
%V 24
%N 1
%D 2024 Feb 1
%M 38302865
%F 3.105
%R 10.1186/s12884-024-06284-7
%X <B>OBJECTIVE: </B>To determine whether non-invasive prenatal testing is an alternative testing option to preimplantation genetic testing (PGT) in pregnant patients.<BR><B>METHODS: </B>This was a retrospective study of the clinical outcomes of patients who underwent PGT and invasive or non-invasive pregnancy testing after euploid blastocyst transfer at our IVF centre between January 2017 and December 2022.<BR><B>RESULTS: </B>In total, 321 patients were enrolled in this study, 138 (43.0%) received invasive pregnancy testing, and 183 (57.0%) patients underwent non-invasive testing. The mean age of the patients in Group 2 was higher than that of the patients in Group 1 (35.64 ± 4.74 vs. 31.04 ± 4.15 years, P < 0.001). The basal LH and AMH levels were higher in Group 1 than in Group 2 (4.30 ± 2.68 vs. 3.40 ± 1.88, P = 0.003; 5.55 ± 11.22 vs. 4.09 ± 3.55, P = 0.012), but the clinical outcomes were not significantly different. Furthermore, the clinical outcomes of patients undergoing invasive testing were similar to those of patients undergoing non-invasive testing with the same PGT indication.<BR><B>CONCLUSIONS: </B>Our results suggest that non-invasive pregnancy testing is a suitable alternative option for detecting the foetal chromosomal status in a PGT cycle. However, the usefulness of non-invasive testing in PGT-M patients is still limited.