%0 Journal Article
%T Complex architecture of cardiac muscle thick filaments revealed.
%A Luther PK
%A Marston SB
%J Trends Pharmacol Sci
%V 45
%N 3
%D 2024 03 31
%M 38302402
%F 17.638
%R 10.1016/j.tips.2024.01.006
%X Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.