%0 Journal Article
%T Genome-wide association study to reveal new candidate genes using single-step approaches for productive traits of Yorkshire pig in Korea.
%A Park J
%J Anim Biosci
%V 37
%N 3
%D 2024 Mar 20
%M 38271983
暂无%R 10.5713/ab.23.0255
%X <B>OBJECTIVE: </B>The objective is to identify genomic regions and candidate genes associated with age to 105 kg (AGE), average daily gain (ADG), backfat thickness (BF), and eye muscle area (EMA) in Yorkshire pig.<BR><B>METHODS: </B>This study used a total of 104,380 records and 11,854 single nucleotide polymorphism (SNP) data obtained from Illumina porcine 60K chip. The estimated genomic breeding values (GEBVs) and SNP effects were estimated by single-step genomic best linear unbiased prediction (ssGBLUP).<BR><B>RESULTS: </B>The heritabilities of AGE, ADG, BF, and EMA were 0.50, 0.49, 0.49, and 0.23, respectively. We identified significant SNP markers surpassing the Bonferroni correction threshold (1.68×10-6), with a total of 9 markers associated with both AGE and ADG, and 4 markers associated with BF and EMA. Genome-wide association study (GWAS) analyses revealed notable chromosomal regions linked to AGE and ADG on Sus scrofa chromosome (SSC) 1, 6, 8, and 16; BF on SSC 2, 5, and 8; and EMA on SSC 1. Additionally, we observed strong linkage disequilibrium on SSC 1. Finally, we performed enrichment analyses using gene ontology and Kyoto encyclopedia of genes and genomes (KEGG), which revealed significant enrichments in eight biological processes, one cellular component, one molecular function, and one KEGG pathway.<BR><B>CONCLUSIONS: </B>The identified SNP markers for productive traits are expected to provide valuable information for genetic improvement as an understanding of their expression.