%0 Journal Article
%T Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats.
%A Souza A
%A Scarim CB
%A Cotrim PC
%A Junior FB
%A Rocha BA
%A Calixto LA
%A Correia CJ
%A de Barros Araújo GL
%A Löbenberg R
%A Bou-Chacra NA
%A Breithaupt-Faloppa AC
%J Nanomedicine (Lond)
%V 19
%N 4
%D 2024 02 25
%M 38270378
%F 6.096
%R 10.2217/nnm-2023-0263
%X Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration.