%0 Review
%T Controversies in the management of anti-TNF therapy in patients with Crohn's disease: a Delphi consensus.
%A González-Lama Y
%A Ricart E
%A Carpio D
%A Bastida G
%A Ceballos D
%A Ginard D
%A Marin-Jimenez I
%A Menchen L
%A Muñoz F
%J BMJ Open Gastroenterol
%V 11
%N 1
%D 2024 Jan 23
%M 38267072
暂无%R 10.1136/bmjgast-2023-001246
%X <B>BACKGROUND: </B>Despite research, there are still controversial areas in the management of Crohn's disease (CD).<BR><B>OBJECTIVE: </B>To establish practical recommendations on using anti-tumour necrosis factor (TNF) drugs in patients with moderate-to-severe CD.<BR><B>METHODS: </B>Clinical controversies in the management of CD using anti-TNF therapies were identified. A comprehensive literature review was performed, and a national survey was launched to examine current clinical practices when using anti-TNF therapies. Their results were discussed by expert gastroenterologists within a nominal group meeting, and a set of statements was proposed and tested in a Delphi process.<BR><B>RESULTS: </B>Qualitative study. The survey and Delphi process were sent to 244 CD-treating physicians (response rate: 58%). A total of 14 statements were generated. All but two achieved agreement. These statements cover: (1) use of first-line non-anti-TNF biological therapy; (2) role of HLA-DQA1*05 in daily practice; (3) attitudes in primary non-response and loss of response to anti-TNF therapy due to immunogenicity; (4) use of ustekinumab or vedolizumab if a change in action mechanism is warranted; (5) anti-TNF drug level monitoring; (6) combined therapy with an immunomodulator.<BR><B>CONCLUSIONS: </B>This document sought to pull together the best evidence, experts' opinions, and treating physicians' attitudes when using anti-TNF therapies in patients with CD.