%0 Journal Article
%T CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1.
%A Wang Y
%A Pan H
%A Gong X
%A Wang Z
%A Qin X
%A Zhou S
%A Zhu C
%A Hu X
%A Chen S
%A Liu H
%A Jin H
%A Pang Q
%A Wu W
%J Pathol Res Pract
%V 254
%N 0
%D 2024 Feb 16
%M 38237400
%F 3.309
%R 10.1016/j.prp.2023.154987
%X The cell proliferation protein 123 (CDC123) is involved in the synthesis of the eukaryotic initiation factor 2 (eIF2), which regulates eukaryotic translation. Although CDC123 is considered a candidate oncogene in breast cancer, its expression and role in Hepatocellular Carcinoma (HCC) remain unknown. Herein, we obtained the CDC123 RNA-seq and clinical prognostic data from the TCGA database. The mRNA level revealed that CDC123 was highly expressed in HCC patients, and Kaplan-Meier analysis implied better prognoses in HCC patients with low CDC123 expression (P < 0.001). The multivariate Cox analysis revealed that the CDC123 level was an independent prognostic factor (P < 0.001). We further confirmed a high CDC123 expression in HCC cell lines. Additionally, we found that CDC123 knockdown in HCC cell lines significantly inhibited cellular proliferation, invasion, and migration. Moreover, CDC123 was co-expressed with the CDK5 Regulatory Subunit-Associated Protein 1 Like 1 (CDKAL1), whose mRNA level was decreased after silencing CDC123. Therefore, we hypothesized that CDC123 promotes HCC progression by regulating CDKAL1.