%0 Journal Article
%T A review on the role of FOXD2-AS1 in human disorders.
%A Ghafouri-Fard S
%A Harsij A
%A Hussen BM
%A Pourmoshtagh H
%A Taheri M
%J Pathol Res Pract
%V 254
%N 0
%D 2024 Feb 9
%M 38211387
%F 3.309
%R 10.1016/j.prp.2024.155101
%X FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is a long non-coding RNA being transcribed from a locus on chromosome 1p33. This transcript has been found to be up-regulated in tumor samples of almost all types of malignancies in association with a significant increase in malignant features. FOXD2-AS1 can affect activity of PI3K/AKT, AKT/mTOR, Hippo/YAP, Notch, NRf2, Wnt/β-catenin, NF-ƙB and ERK/MAPK pathways. Furthermore, it can enhance stem cell properties in cancer cells and prompt epithelial-mesenchymal transition. It is also involved in induction of resistance to a variety of anticancer agents such as adriamycin, cisplatin, 5-fluorouracil, temozolomide and gemcitabine. This article summarizes the impact of FOXD2-AS1 in diverse human disorders.