%0 Journal Article
%T Stereotactic radiotherapy for ventricular tachycardia: A study protocol.
%A Kawamura M
%A Shimojo M
%A Inden Y
%A Kamomae T
%A Okudaira K
%A Komada T
%A Aoki S
%A Shindo Y
%A Yasui R
%A Yanagi Y
%A Okumura M
%A Yamada T
%A Kozai Y
%A Oie Y
%A Kato Y
%A Ishihara S
%A Murohara T
%A Naganawa S
%J F1000Res
%V 12
%N 0
%D 2023
%M 38204487
暂无%R 10.12688/f1000research.138758.2
%X Currently, the standard curative treatment for ventricular tachycardia (VT) and ventricular fibrillation (VF) is radiofrequency catheter ablation. However, when the VT circuit is deep in the myocardium, the catheter may not be delivered, and a new, minimally invasive treatment using different energies is desired.
This is a protocol paper for a feasibility study designed to provide stereotactic radiotherapy for refractory VT not cured by catheter ablation after at least one catheter ablation. The primary end point is to evaluate the short-term safety of this treatment and the secondary endpoint is to evaluate its efficacy as assessed by the reduction in VT episode. Cyberknife M6 radiosurgery system will be used for treatment, and the prescribed dose to the target will be 25Gy in one fraction. The study will be conducted on three patients.
Since catheter ablation is the only treatment option for VT that is covered by insurance in Japan, there is currently no other treatment for VT/VF that cannot be cured by catheter ablation. We hope that this feasibility study will provide hope for patients who are currently under the stress of ICD activation.
The study has been registered in the Japan Registry of Clinical Trials (jRCTs042230030).