%0 Journal Article
%T The human Y and inactive X chromosomes similarly modulate autosomal gene expression.
%A San Roman AK
%A Skaletsky H
%A Godfrey AK
%A Bokil NV
%A Teitz L
%A Singh I
%A Blanton LV
%A Bellott DW
%A Pyntikova T
%A Lange J
%A Koutseva N
%A Hughes JF
%A Brown L
%A Phou S
%A Buscetta A
%A Kruszka P
%A Banks N
%A Dutra A
%A Pak E
%A Lasutschinkow PC
%A Keen C
%A Davis SM
%A Lin AE
%A Tartaglia NR
%A Samango-Sprouse C
%A Muenke M
%A Page DC
%J Cell Genom
%V 4
%N 1
%D 2024 Jan 10
%M 38190107
暂无%R 10.1016/j.xgen.2023.100462
%X Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46th chromosome is a Y; in females it is an "inactive" X (Xi). Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects. Studying sex chromosome structural anomalies, promoters of Xi- and Y-responsive genes, and CRISPR inhibition, we traced part of this shared effect to homologous transcription factors-ZFX and ZFY-encoded by Chr X and Y. This demonstrates sex-shared mechanisms by which Xi and Y modulate autosomal expression. Combined with earlier analyses of sex-linked gene expression, our studies show that 21% of all genes expressed in lymphoblastoid cells or fibroblasts change expression significantly in response to Xi or Y chromosomes.