%0 Journal Article
%T Feasibility study of multiple-energy Bragg peak proton FLASH on a superconducting gantry with large momentum acceptance.
%A Zeng Y
%A Li H
%A Wang W
%A Liu X
%A Qin B
%A Dai S
%A Pang B
%A Liu M
%A Quan H
%A Yang K
%A Chang Y
%A Yang Z
%J Med Phys
%V 51
%N 3
%D 2024 Mar 3
%M 38169535
%F 4.506
%R 10.1002/mp.16932
%X <B>BACKGROUND: </B>While the Bragg peak proton beam (BP) is capable of superior target conformity and organs-at-risk sparing than the transmission proton beam (TB), its efficacy in FLASH-RT is hindered by both a slow energy switching process and the beam current. A universal range shifter (URS) can pull back the high-energy proton beam while preserving the beam current. Meanwhile, a superconducting gantry with large momentum acceptance (LMA-SC gantry) enables fast energy switching.<BR><B>OBJECTIVE: </B>This study explores the feasibility of multiple-energy BP FLASH-RT on the LMA-SC gantry.<BR><B>METHODS: </B>A simultaneous dose and spot map optimization algorithm was developed for BP FLASH-RT treatment planning to improve the dose delivery efficiency. The URS was designed to be 0-27 cm thick, with 1 cm per step. BP plans using the URS were optimized using single-field optimization (SFO) and multiple-field optimization (MFO) for ten prostate cancer patients and ten lung cancer patients. The plan delivery parameters, dose, and dose rate metrics of BP plans were compared to those of TB plans using the parameters of the LMA-SC gantry.<BR><B>RESULTS: </B>Compared to TB plans, BP plans significantly reduced MUs by 42.7% (P < 0.001) with SFO and 33.3% (P < 0.001) with MFO for prostate cases. For lung cases, the reduction in MUs was 56.8% (P < 0.001) with SFO and 36.4% (P < 0.001) with MFO. BP plans also outperformed TB plans by reducing mean normal tissue doses. BP-SFO plans achieved a reduction of 56.7% (P < 0.001) for prostate cases and 57.7% (P < 0.001) for lung cases, while BP-MFO plans achieved a reduction of 54.2% (P < 0.001) for the prostate case and 40.0% (P < 0.001) for lung cases. For both TB and BP plans, normal tissues in prostate and lung cases received 100.0% FLASH dose rate coverage (>40 Gy/s).<BR><B>CONCLUSIONS: </B>By utilizing the URS and the LMA-SC gantry, it is possible to perform multiple-energy BP FLASH-RT, resulting in better normal tissue sparing, as compared to TB plans.