%0 Journal Article
%T FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases.
%A Breeze CE
%A Haugen E
%A Gutierrez-Arcelus M
%A Yao X
%A Teschendorff A
%A Beck S
%A Dunham I
%A Stamatoyannopoulos J
%A Franceschini N
%A Machiela MJ
%A Berndt SI
%J Genome Biol
%V 25
%N 1
%D 2024 01 2
%M 38167104
暂无%R 10.1186/s13059-023-03126-1
%X The majority of disease-associated variants identified through genome-wide association studies are located outside of protein-coding regions. Prioritizing candidate regulatory variants and gene targets to identify potential biological mechanisms for further functional experiments can be challenging. To address this challenge, we developed FORGEdb ( https://forgedb.cancer.gov/ ; https://forge2.altiusinstitute.org/files/forgedb.html ; and https://doi.org/10.5281/zenodo.10067458 ), a standalone and web-based tool that integrates multiple datasets, delivering information on associated regulatory elements, transcription factor binding sites, and target genes for over 37 million variants. FORGEdb scores provide researchers with a quantitative assessment of the relative importance of each variant for targeted functional experiments.