%0 Multicenter Study
%T Relevance of different prognostic scores in primary CNS lymphoma in the era of intensified treatment regimens: A retrospective, multicenter analysis of 174 patients.
%A Zeremski V
%A Adolph L
%A Beer S
%A Berisha M
%A Jacobs B
%A Kahl C
%A Koenecke C
%A Kropf S
%A Panse J
%A Petersen J
%A Schmidt-Hieber M
%A Schneider J
%A Vucinic V
%A Walter J
%A Weigert O
%A Witte HM
%A Mougiakakos D
%J Eur J Haematol
%V 112
%N 4
%D 2024 Apr 2
%M 38164819
%F 3.674
%R 10.1111/ejh.14159
%X <B>OBJECTIVE: </B>Treatment intensification (including consolidative high-dose chemotherapy with autologous stem cell transplantation [HDT-ASCT]) significantly improved outcome in primary central nervous system lymphoma (PCNSL) patients.<BR><B>METHODS: </B>We conducted a multicenter, retrospective analysis of newly diagnosed PCNSL patients, treated with intensified treatment regimens. The following scores were evaluated in terms of overall survival (OS) and progression-free survival (PFS): Memorial Sloan-Kettering Cancer Center (MSKCC), International Extranodal Lymphoma Study Group (IELSG), and three-factor (3F) prognostic score. Further, all scores were comparatively investigated for model quality and concordance.<BR><B>RESULTS: </B>Altogether, 174 PCNSL patients were included. One hundred and five patients (60.3%) underwent HDT-ASCT. Two-year OS and 2-year PFS for the entire population were 73.3% and 48.5%, respectively. The MSKCC (p = .003) and 3F score (p < .001), but not the IELSG score (p = .06), had the discriminatory power to identify different risk groups for OS. In regard to concordance, the 3F score (C-index [0.71]) outperformed both the MSKCC (C-index [0.64]) and IELSG (C-index [0.53]) score. Moreover, the superiority of the 3F score was shown for PFS, successfully stratifying patients in three risk groups, which also resulted in the highest C-index (0.66).<BR><B>CONCLUSIONS: </B>The comparative analysis of established PCNSL risk scores affirm the clinical utility of the 3F score stratifying the widest prognostic spectrum among PCNSL patients treated with intensified treatment approaches.