%0 Journal Article
%T Nanomaterials-Based Field-Effect Transistor for Protein Sensing: New Advances.
%A Aftab S
%A Li X
%A Hussain S
%A Aslam M
%A Hegazy HH
%A Abd-Rabboh HSM
%A Koyyada G
%A Kim JH
%J ACS Sens
%V 9
%N 1
%D 2024 01 26
%M 38156963
%F 9.618
%R 10.1021/acssensors.3c01728
%X It is crucial for early stage medical diagnostics to identify disease biomarkers at ultralow concentrations. A wide range of analytes can be identified using low-dimensional materials to build highly sensitive, targeted, label-free, field-effect transistor (FET) biosensors. Two-dimensional (2D) materials are preferable for high-performance biosensing because of their dramatic change in resistivity upon analyte adsorption or biomarker detection, tunable electronic properties, high surface activities, adequate stability, and layer-dependent semiconducting properties. We give a succinct overview of interesting applications for protein sensing with various architectural styles, such as 2D transition metal dichalcogenides (TMDs)-based FETs that include carbon nanotubes (CNTs), graphene (Gr), reduced graphene oxide (rGr), 2D transition-metal carbides (MXene), and Gr/MXene heterostructures. Because it might enable individuals to perform better, this review will be an important contribution to the field of medical science. These achievements demonstrate point-of-care diagnostics' abilities to detect biomarkers at ultrahigh performance levels. A summary of the present opportunities and challenges appears in the conclusion.