%0 Journal Article
%T Phosphatidic acid signaling and function in nuclei.
%A Yao S
%A Kim SC
%A Li J
%A Tang S
%A Wang X
%J Prog Lipid Res
%V 93
%N 0
%D 2024 Jan 26
%M 38154743
%F 14.673
%R 10.1016/j.plipres.2023.101267
%X Membrane lipidomes are dynamic and their changes generate lipid mediators affecting various biological processes. Phosphatidic acid (PA) has emerged as an important class of lipid mediators involved in a wide range of cellular and physiological responses in plants, animals, and microbes. The regulatory functions of PA have been studied primarily outside the nuclei, but an increasing number of recent studies indicates that some of the PA effects result from its action in nuclei. PA levels in nuclei are dynamic in response to stimuli. Changes in nuclear PA levels can result from activities of enzymes associated with nuclei and/or from movements of PA generated extranuclearly. PA has also been found to interact with proteins involved in nuclear functions, such as transcription factors and proteins undergoing nuclear translocation in response to stimuli. The nuclear action of PA affects various aspects of plant growth, development, and response to stress and environmental changes.