%0 Journal Article
%T Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case.
%A Tao T
%A Cen J
%A Xu C
%A Chen Y
%A Cao Y
%A Gong Y
%A Zhu M
%A Chen S
%A Zhang Q
%A Yao L
%J Mol Carcinog
%V 63
%N 4
%D 2024 Apr 28
%M 38153216
%F 5.139
%R 10.1002/mc.23672
%X Acute promyelocytic leukemia (APL) with typically PML::RARA fusion gene caused by t (15;17) (q22; q12) was distinguished from other types of acute myeloid leukemia. In a subset of patients with APL, t (15;17) (q22;q21) and PML::RARA fusion cannot be detected. In this report, we identified the coexistence of STAT3::RARA and RARA::STAT5b fusions for the first time in a variant APL patient lacking t (15;17)(q22;q21)/PML::RARA fusion. Then, this patient was resistant to all-trans retinoic acid combined arsenic trioxide chemotherapy. Accurate detection of RARA gene partners is crucial for variant APL, and effective therapeutic regime is urgently needed.