%0 Journal Article
%T Evaluation of a Novel Microfocused Ultrasound with Three-Dimensional Digital Imaging for Facial Tightening: A Prospective, Randomized, Controlled Trial.
%A Zhu J
%A Han Y
%A Liu Y
%A Chang R
%A Gao W
%A Gong X
%A Zhu Y
%A Shang Y
%A Shen L
%A Yu W
%A Lyu D
%A Lin X
%J Dermatol Ther (Heidelb)
%V 14
%N 1
%D 2024 Jan 15
%M 38100073
暂无%R 10.1007/s13555-023-01078-9
%X <B>BACKGROUND: </B>The excellent efficacy is mitigated by the limited safety profile of microfocused ultrasound procedures.<BR><B>OBJECTIVE: </B>We sought to assess the safety and tightening efficacy of a novel microfocused ultrasound.<BR><B>METHODS: </B>The randomized middle and lower face and submental region of the participants were treated with the novel device using the following transducers: M4.5, D4.5, M3.0, and D3.0. Improvement in paired comparison of pretreatment and posttreatment photographs, three-dimensional (3D) volumetric assessments, skin thickness measured by B-ultrasonography, and skin photoaging parameters were evaluated. Adverse events and patient satisfaction were also recorded.<BR><B>RESULTS: </B>A total of 20 participants (20 female) were enrolled. Fourteen of 20 participants (70%) were judged to show clinically significant facial tightening during 3-month follow-up (P < 0.05). The mean volumetric change in the lower face, as quantitatively assessed after 3 months was -0.29 mL compared with +0.42 mL on the control side (P < 0.05). The VAS pain score was 3.00 ± 1.19 without any oral or intramuscular anesthesia.<BR><B>CONCLUSIONS: </B>A small sample size, lack of clinical scales, and impersonalized treatment parameters. The novel microfocused ultrasound appears to be a safe and effective modality for lower-face tightening.<BR><B>BACKGROUND: </B>ChiCTR 2200064666.