%0 Case Reports
%T Cardiogenic shock after 5-fluorouracil administration: a case report and literature review.
%A Vanoverbeke L
%A Wouter H
%A François D
%A Ivan E
%J Eur Heart J Case Rep
%V 7
%N 12
%D 2023 Dec
%M 38099075
暂无%R 10.1093/ehjcr/ytad596
%X <B>UNASSIGNED: </B>Cardiogenic shock is a rare adverse event of 5-fluorouracil (5-FU) administration. Because of its rare entity, little is known about epidemiologic and clinical features of 5-FU-induced cardiogenic shock, and recommendations about specific treatment are missing.<BR><B>UNASSIGNED: </B>We present a case of cardiogenic shock and ventricular arrhythmia due to 5-FU-induced toxic cardiomyopathy treated with vasopressor and inotropic drugs in combination with intra-aortic balloon pump. Because of persistent haemodynamic instability, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and Impella were implanted as a bridge to recovery. Systolic function recovered completely and the patient was weaned successfully.<BR><B>UNASSIGNED: </B>This case demonstrates toxic cardiomyopathy as a rare and potentially lethal cardiac adverse event of 5-FU administration. This case emphasizes the importance of mechanical support as bridging therapy to recovery of cardiac function.