%0 Journal Article
%T The role of angiotensin receptor blockers in treating epilepsy: a review.
%A Shaikh TG
%A Hasan SFS
%A Ahmed H
%A Kazi AI
%A Mansoor R
%J Neurol Sci
%V 45
%N 4
%D 2024 Apr 11
%M 38079018
%F 3.83
%R 10.1007/s10072-023-07249-y
%X Epilepsy is a chronic brain disease with a global prevalence of 70 million people. According to the World Health Organization, roughly 5 million new cases are diagnosed every year. Anti-seizure drugs are the treatment of choice. However, in roughly one third of the patients, these drugs fail to produce the desired effect. As a result, finding novel treatments for epilepsy becomes inevitable. Recently, angiotensin receptor blockers have been proposed as a treatment to reduce the over-excitation of neurons in epilepsy. For this purpose, we conducted a review using Medline/PubMed and Google Scholar using the relevant search terms and extracted the relevant data in a table. Our review suggests that this novel approach has a very high potential to treat epilepsy, especially in those patients who fail to respond to conventional treatment options. However, more extensive and human-based trials should be conducted to reach a decisive conclusion. Nevertheless, the use of ARBs in patients with epilepsy should be carefully monitored keeping the adverse effects in mind.