%0 English Abstract
%T [Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii].
%A Kravchuk OI
%A Finoshin AD
%A Mikhailov KV
%A Ziganshin RH
%A Adameyko KI
%A Gornostaev NG
%A Zhurakovskaya AI
%A Mikhailov VS
%A Shagimardanova EI
%A Lyupina YV
%J Mol Biol (Mosk)
%V 57
%N 6
%D 2023 Nov-Dec
%M 38062963
暂无%R 10.31857/S0026898423060113, EDN: QFTCTO
%X δ-Aminolevulinic acid dehydratase (ALAD) is a key enzyme of the cytoplasmic heme biosynthesis pathway. The primary structure of the ALAD gene, the multimeric structure of the ALAD/hemB protein, and ALAD expression during the annual reproductive cycle were studied in the cold-water marine sponge Halisarca dujardinii. The results implicated the GATA-1 transcription factor and DNA methylation in regulating ALAD expression. Re-aggregation of sponge cells was accompanied by a decrease in ALAD expression and a change in the cell content of an active ALAD/hemB form. Further study of heme biosynthesis and the role of ALAD/hemB in morphogenesis of basal animals may provide new opportunities for treating pathologies in higher animals.