%0 Letter
%T Recurrence and malignant risk of ameloblastoma: A demographic study of 1626 cases from east China.
%A Liu W
%A Zheng C
%A Zhang X
%A Hu H
%J Oral Oncol
%V 148
%N 0
%D 2024 Jan 6
%M 38061123
%F 5.972
%R 10.1016/j.oraloncology.2023.106651
%X <B>BACKGROUND: </B>Ameloblastoma is characterized by aggressive nature, high recurrence rate, occasional malignant transformation, but recurrence and malignant incidence of ameloblastoma are not yet addressed by a large-scale case series study.<BR><B>METHODS: </B>This study provided a detailed description of the relationship between demographic characteristics and recurrence and malignant cases with different clinical types of ameloblastoma (n = 1626).<BR><B>RESULTS: </B>The overall incidence of recurrence and malignancy was 17.2 % and 3.4 %, respectively. Notably, we observed that there were multiple recurrent episodes (mean time, 24.3-28.7 months) among ameloblastoma patients. Multivariate analysis revealed that age of > 45 years (odds ratios (OR), 2.10; 95 % confidence interval (CI), 1.17-3.76), male (OR, 3.24; 95 %CI, 1.49-6.99), maxilla (OR, 5.58; 95 %CI, 3.11-10.0), and pre-existing recurrence (OR, 3.79; 95 %CI, 2.05-7.01) as independent factors were associated significantly with increased risk of malignancy.<BR><B>CONCLUSIONS: </B>Identification of the clinical factors responsible for increased risk of malignancy provides better insight in management planning for ameloblastoma.