%0 Journal Article
%T A case of bullous pemphigoid and renal disease after dipeptidyl peptidase 4 inhibitor administration.
%A Suenaga A
%A Sawa N
%A Oba Y
%A Ikuma D
%A Sekine A
%A Yamanouchi M
%A Hasegawa E
%A Mizuno H
%A Suwabe T
%A Hayashi N
%A Kono K
%A Kinowaki K
%A Ohashi K
%A Miyazono M
%A Yamaguchi Y
%A Ubara Y
%J CEN Case Rep
%V 0
%N 0
%D 2023 Dec 6
%M 38055184
暂无%R 10.1007/s13730-023-00835-1
%X A 62-year-old man with type 2 diabetes was admitted because of a decrease in estimated glomerular filtration rate from 72 to 17.5 mL/min/1.73 m2 in 10 years and development of widespread bullous skin lesions. His hemoglobin A1c level had been maintained at 6.0-7.0% for 10 years with a dipeptidyl peptidase (DPP)-4 inhibitor. Skin biopsy showed typical bullous pemphigoid, and kidney biopsy showed tubulointerstitial nephritis with eosinophilic infiltration and glomerular endothelial cell proliferation. After discontinuing the DPP-4 inhibitor, skin lesions improved, and renal decline slowed. This case indicates that DPP-4 inhibitors can cause not only skin lesions but also renal disease.