%0 Journal Article
%T Transcatheter aortic valve durability, predictors of bioprosthetic valve dysfunction, longer-term outcomes - a review.
%A Šolc AJ
%A Línková H
%A Toušek P
%J Expert Rev Med Devices
%V 21
%N 1
%D 2024 Jan-Feb 30
%M 38032186
%F 3.439
%R 10.1080/17434440.2023.2288275
%X <B>UNASSIGNED: </B>Transcatheter aortic valve implantation (TAVI) is one of the most significant inventions in cardiology, as it provides a viable minimally invasive treatment option for patients with aortic stenosis, the most common valvular disease in the developed world and one with a poor prognosis when left untreated. Using data available to date, this review aims to discuss and identify possible predictors of TAVI valve durability - an essential requirement for the device's wide-spread use, especially in younger patients.<BR><B>UNASSIGNED: </B>This article explores the main causes of bioprosthetic valve dysfunction (BVD) based on pathophysiology and available data, and reviews possible predictors of BVD including prosthesis-related, procedure-related, and patient-related factors. An emphasis is made on affectable predictors, which could potentially be targeted with prevention management and improve valve durability. A literature search of online medical databases was conducted using relevant key words and dates; significant clinical trials were identified. A brief overview of important randomized controlled trials with mid to long-term follow-up is included in this article.<BR><B>UNASSIGNED: </B>Identifying modifiable predictors of valve dysfunction presents an opportunity to enhance and predict valve durability - a necessity as patients with longer life-expectancies are being considered for the procedure.