%0 Randomized Controlled Trial
%T Effects of caloric and nutrient content of oral fluids on gastric emptying in volunteers: a randomised crossover study.
%A Ali M
%A Uslu A
%A Bodin L
%A Andersson H
%A Modiri AR
%A Frykholm P
%J Br J Anaesth
%V 132
%N 2
%D 2024 Feb 25
%M 38008651
%F 11.719
%R 10.1016/j.bja.2023.10.030
%X <B>BACKGROUND: </B>Previous studies demonstrated conflicting results regarding the determinants of gastric emptying for fluids. Our aim was to compare gastric emptying times of fluids with different caloric and nutrient content.<BR><B>METHODS: </B>Healthy adult volunteers underwent gastric ultrasound assessment for 4 h after consuming beverages with different caloric and nutrient content using a crossover design (oat drink with 3% fat [310 kcal], mango juice [310 kcal], oat drink with 0.5% fat [185 kcal], and blackcurrant juice [175 kcal]). Gastric emptying time, gastric content volume, and the area under the curve (AUC) of gastric content volume-time profiles were calculated.<BR><B>RESULTS: </B>Eight females and eight males completed the study protocol. The mean (sd) gastric emptying times were 89 (32) min for blackcurrant juice, 127 (54) min for oat drink with 0.5% fat, 135 (36) min for mango juice, and 152 (40) min for oat drink with 3% fat. Gastric emptying times were slower for oat drink with 3% fat (P=0.007) and mango juice (P=0.025) than for blackcurrant juice. At 1 h after ingestion, gastric content volume was greater for mango juice (P=0.021) and oat drink with 3% fat (P=0.003) than for blackcurrant juice. The AUC was greater for oat drink with 3% fat than mango juice (P=0.029), oat drink with 0.5% fat (P=0.004), and blackcurrant juice (P=0.002), and for mango juice than blackcurrant juice (P=0.019).<BR><B>CONCLUSIONS: </B>Caloric and nutrient content significantly affected gastric emptying times. A high-calorie fruit juice (mango) exhibited delayed emptying times compared with a low-calorie fruit juice (blackcurrant).<BR><B>BACKGROUND: </B>ISRCTN17147574.