%0 Journal Article
%T Factors associated with unexplained sudden deaths among adults aged 18-45 years in India - A multicentric matched case-control study.
%A Ponnaiah M
%A Bhatnagar T
%A Abdulkader RS
%A Elumalai R
%A Surya J
%A Jeyashree K
%A Kumar MS
%A Govindaraju R
%A Thangaraj JWV
%A Aggarwal HK
%A Balan S
%A Baruah TD
%A Basu A
%A Bavaskar Y
%A Bhadoria AS
%A Bhalla A
%A Bhardwaj P
%A Bhat R
%A Chakravarty J
%A Chandy GM
%A Gupta BK
%A Kakkar R
%A Karnam AHF
%A Kataria S
%A Khambholja J
%A Kumar D
%A Kumar N
%A Lyngdoh M
%A Meena MS
%A Mehta K
%A Sheethal MP
%A Mukherjee S
%A Mundra A
%A Murugan A
%A Narayanan S
%A Nathan B
%A Ojah J
%A Patil P
%A Pawar S
%A Ruban ACP
%A Vadivelu R
%A Rana RK
%A Boopathy SN
%A Priya S
%A Sahoo SK
%A Shah A
%A Shameem M
%A Shanmugam K
%A Shivnitwar SK
%A Singhai A
%A Srivastava S
%A Sulgante S
%A Talukdar A
%A Verma A
%A Vohra R
%A Wani RT
%A Bathula B
%A Kumari G
%A Kumar DS
%A Narasimhan A
%A Krupa NC
%A Senguttuvan T
%A Surendran P
%A Tamilmani D
%A Turuk A
%A Kumar G
%A Murkherjee A
%A Aggarwal R
%A Murhekar MV
%A  
%J Indian J Med Res
%V 158
%N 4
%D 2023 Oct 1
%M 37988028
%F 5.274
%R 10.4103/ijmr.ijmr_2105_23
%X <B>UNASSIGNED: </B>In view of anecdotal reports of sudden unexplained deaths in India's apparently healthy young adults, linking to coronavirus disease 2019 (COVID-19) infection or vaccination, we determined the factors associated with such deaths in individuals aged 18-45 years through a multicentric matched case-control study.<BR><B>METHODS: </B>This study was conducted through participation of 47 tertiary care hospitals across India. Cases were apparently healthy individuals aged 18-45 years without any known co-morbidity, who suddenly (<24 h of hospitalization or seen apparently healthy 24 h before death) died of unexplained causes during 1 st October 2021-31 st March 2023. Four controls were included per case matched for age, gender and neighborhood. We interviewed/perused records to collect data on COVID-19 vaccination/infection and post-COVID-19 conditions, family history of sudden death, smoking, recreational drug use, alcohol frequency and binge drinking and vigorous-intensity physical activity two days before death/interviews. We developed regression models considering COVID-19 vaccination ≤42 days before outcome, any vaccine received anytime and vaccine doses to compute an adjusted matched odds ratio (aOR) with 95 per cent confidence interval (CI).<BR><B>RESULTS: </B>Seven hundred twenty nine cases and 2916 controls were included in the analysis. Receipt of at least one dose of COVID-19 vaccine lowered the odds [aOR (95% CI)] for unexplained sudden death [0.58 (0.37, 0.92)], whereas past COVID-19 hospitalization [3.8 (1.36, 10.61)], family history of sudden death [2.53 (1.52, 4.21)], binge drinking 48 h before death/interview [5.29 (2.57, 10.89)], use of recreational drug/substance [2.92 (1.1, 7.71)] and performing vigorous-intensity physical activity 48 h before death/interview [3.7 (1.36, 10.05)] were positively associated. Two doses lowered the odds of unexplained sudden death [0.51 (0.28, 0.91)], whereas single dose did not.<BR><B>UNASSIGNED: </B>COVID-19 vaccination did not increase the risk of unexplained sudden death among young adults in India. Past COVID-19 hospitalization, family history of sudden death and certain lifestyle behaviors increased the likelihood of unexplained sudden death.