%0 Journal Article
%T Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases: A Systematic Review.
%A Skare TL
%A Hauz E
%A de Carvalho JF
%J Mediterr J Rheumatol
%V 34
%N 3
%D 2023 Sep
%M 37941864
暂无%R 10.31138/mjr.20230825.dd
%X <B>UNASSIGNED: </B>Dehydroepiandrosterone (DHEA) is an adrenal hormone used to treat rheumatic conditions such as systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), rheumatoid arthritis (RA) with controversial results.<BR><B>UNASSIGNED: </B>To review the results of DHEA use in rheumatic diseases.<BR><B>UNASSIGNED: </B>PubMed, Scielo, Scopus, and Embase databases were systematically searched for articles on the treatment of rheumatic diseases with DHEA between 1966 and April 2023.<BR><B>UNASSIGNED: </B>Twenty-one studies were identified: 13 in SLE, 5 in SS, 2 in RA, and 1 in fibromyalgia. DHEA use in SLE has shown a mild to moderate effect on disease activity, a positive effect on bone mineral density (BMD), and improved fatigue. The studies on SS showed a decrease in symptoms of dry mouth, but its performance did not differ from placebo in disease activity. In RA, a questionable effect on disease activity was noted. The only study on fibromyalgia failed to show any improvement. The drug was well tolerated; mild androgenic effects were the most common complaints.<BR><B>UNASSIGNED: </B>DHEA seems to have a place in SLE treatment, where it improves BMD and disease activity. The use in RA, SS, and FM is questionable.