%0 Journal Article
%T The clinical features of patients with seizure freedom and failure after total corpus callosotomy for childhood-onset refractory epilepsy.
%A Liu Y
%A Zhang J
%A Ren Y
%A Wu H
%A Li H
%A Dong S
%A Liu X
%A Du C
%A Meng Q
%A Zhang H
%J Br J Neurosurg
%V 0
%N 0
%D 2023 Nov 5
%M 37927066
%F 1.124
%R 10.1080/02688697.2023.2273840
%X <B>UNASSIGNED: </B>Corpus callosotomy is a palliative surgery for medically refractory epilepsy. We aim to analyze the clinical features of patients with seizure freedom and failure after total corpus callosotomy for childhood-onset refractory epilepsy.<BR><B>UNASSIGNED: </B>We retrospectively reviewed the clinical courses of patients with childhood-onset refractory epilepsy undergoing total corpus callosotomy between May 2009 and March 2019. Seizure outcome at the last follow-up was the primary outcome. The clinical features of patients with seizure freedom and failure after callosotomy were compared.<BR><B>UNASSIGNED: </B>Eighty patients with childhood-onset refractory epilepsy underwent total corpus callosotomy; 15 (18.8%) obtained freedom from all seizures and 19 (23.8%) had unworthwhile improvement and failure. The mean ages at seizure onset in patients with seizure freedom and failure after callosotomy were 5.7 and 5.9 years; and mean seizure durations were 9.4 and 11.5 years, respectively. Univariate analysis found epilepsy syndrome (p = 0.047), mental retardation (p = 0.007), previous medical history (p = 0.004), ≥10 seizures per day (p = 0.024), theta waves in the background electroencephalogram (p = 0.024), and acute postoperative seizure (p = 0.000) were associated with failure after callosotomy. Seizure freedom after callosotomy was more common among patients with less than 10 seizures per day.<BR><B>UNASSIGNED: </B>Total corpus callosotomy is an effective palliative procedure for childhood-onset refractory epilepsy, particularly for patients with specific clinical characteristics. Callosotomy has a high seizure-free rate in well-selected patients.