%0 Journal Article
%T Copeptin in autosomal dominant polycystic kidney disease: real-world experiences from a large prospective cohort study.
%A Arjune S
%A Oehm S
%A Todorova P
%A Gansevoort RT
%A Bakker SJL
%A Erger F
%A Benzing T
%A Burst V
%A Grundmann F
%A Antczak P
%A Müller RU
%J Clin Kidney J
%V 16
%N 11
%D 2023 Nov
%M 37915893
%F 5.86
%R 10.1093/ckj/sfad118
%X <B>UNASSIGNED: </B>The identification of new biomarkers in autosomal-dominant polycystic kidney disease (ADPKD) is crucial to improve and simplify prognostic assessment as a basis for patient selection for targeted therapies. Post hoc analyses of the TEMPO 3:4 study indicated that copeptin could be one of those biomarkers.<BR><B>UNASSIGNED: </B>Copeptin was tested in serum samples from patients of the AD(H)PKD study. Serum copeptin levels were measured using a time-resolved amplified cryptate emission (TRACE)-based assay. In total, we collected 711 values from 389 patients without tolvaptan treatment and a total of 243 values (of which 64 were pre-tolvaptan) from 94 patients on tolvaptan. These were associated with rapid progression and disease-causing gene variants and their predictive capacity tested and compared with the Mayo Classification.<BR><B>UNASSIGNED: </B>As expected, copeptin levels showed a significant negative correlation with estimated glomerular filtration rate (eGFR). Measurements on tolvaptan showed significantly higher copeptin levels (9.871 pmol/L vs 23.90 pmol/L at 90/30 mg; P < .0001) in all chronic kidney disease stages. Linear regression models (n = 133) show that copeptin is an independent predictor of eGFR slope. A clinical model (including eGFR, age, gender, copeptin) was nearly as good (R2 = 0.1196) as our optimal model (including height-adjusted total kidney volume, eGFR, copeptin, R2 = 0.1256). Adding copeptin to the Mayo model improved future eGFR estimation.<BR><B>UNASSIGNED: </B>Copeptin levels are associated with kidney function and independently explained future eGFR slopes. As expected, treatment with tolvaptan strongly increases copeptin levels.