%0 Journal Article
%T Increased circulating microRNA-21 level as a potential indicator for predicting a higher risk of incident fragility fractures.
%A Si ZX
%A Zhou SF
%A Shen ZL
%A Yan JL
%J J Osteopath Med
%V 124
%N 3
%D 2024 Mar 1
%M 37883102
暂无%R 10.1515/jom-2023-0174
%X <B>BACKGROUND: </B>As a common disease in the elderly, osteoporosis clearly increases the risk of fractures, leading to higher mortality, but the current markers to estimate the risk of fractures are limited. MicroRNA-21 (miR-21) may play an important role in osteoporosis, but the link of this biomarker with fractures was undetermined.<BR><B>OBJECTIVE: </B>We aimed to investigate the association between miR-21 levels and the presence of fragility fractures.<BR><B>METHODS: </B>A total of 200 patients were recruited and miR-21 was collected from baseline serum. The correlation between miR-21 and the fracture risk assessment tool (FRAX) score was analyzed. The incidence of fragility fractures was presented by Kaplan-Meier analysis, and Cox regression analysis was utilized to evaluate risk factors. The diagnostic value of miR-21 was conducted by the area under curve (AUC).<BR><B>RESULTS: </B>The FRAX score was significantly associated with miR-21 level (p<0.001). According to the 50th percentile of miR-21 content in the overall distribution, the cumulative incidence of fragility fractures was significantly higher in patients with higher miR-21 levels than those with lower levels (75.4, 95 % CI: 69.0-81.8 vs. 59.2, 95 % CI: 42.1-76.3, p<0.001). The results of the Cox regression analysis showed that the miR-21 level was an independent risk factor linked to the incidence of fracture (p=0.005). The optimal cut-off value of the miR-21 was 6.08, and the AUC for predicting fracture was 0.718 (95 % CI, 0.645-0.790).<BR><B>CONCLUSIONS: </B>This study showed that miR-21 has optimal diagnostic performance in the discrimination of fragility fracture, and the circulating miR-21 level in predicting the risk of fragility fracture may have a certain value.