%0 Journal Article
%T A Korean family with RHD*DNT only detectable after anti-D alloimmunization.
%A Shin DW
%A Lee GH
%A Kim H
%A So KA
%A Hong YJ
%A Hur M
%A Park KU
%J Am J Clin Pathol
%V 161
%N 2
%D 2024 Feb 1
%M 37852281
%F 5.4
%R 10.1093/ajcp/aqad132
%X <B>OBJECTIVE: </B>Identification of DNT, a rare partial D, can be challenging, as it is difficult to distinguish from D+. This study aimed to identify DNT individuals by analyzing the DNT proband's family members, characterize DNT, and propose management strategies.<BR><B>METHODS: </B>Family members of the first Korean DNT proband were recruited. RHD genotyping was conducted, and weak D tests were carried out using several anti-D reagents.<BR><B>RESULTS: </B>Three DNT individuals were identified among 6 family members, including 1 with an anti-D alloantibody. As DNT red cells exhibited strong reactivity with all anti-D clones, DNT was serologically indistinguishable from D+. Moreover, unusual serologic findings in DNT individuals only became apparent after anti-D alloimmunization.<BR><B>CONCLUSIONS: </B>We recommend DNT individuals as candidates for Rh immune globulin prophylaxis during the perinatal period and transfusions with D- blood components. An anticipatory RHD genotyping is suggested for partial D family members to prevent potential partial D individuals from becoming alloimmunized.