%0 Journal Article
%T Biologic versus synthetic prosthesis for chest wall reconstruction: a matched analysis.
%A Vanstraelen S
%A Bains MS
%A Dycoco J
%A Adusumilli PS
%A Bott MJ
%A Downey RJ
%A Huang J
%A Isbell JM
%A Molena D
%A Park BJ
%A Rusch VW
%A Sihag S
%A Allen RJ
%A Cordeiro PG
%A Coriddi MR
%A Dayan JH
%A Disa JJ
%A Matros E
%A McCarthy CM
%A Nelson JA
%A Stern C
%A Shahzad F
%A Mehrara B
%A Jones DR
%A Rocco G
%J Eur J Cardiothorac Surg
%V 64
%N 6
%D 2023 Dec 1
%M 37846030
%F 4.534
%R 10.1093/ejcts/ezad348
%X <B>OBJECTIVE: </B>The aim of this study was to compare postoperative outcomes between biologic and synthetic reconstructions after chest wall resection in a matched cohort.<BR><B>METHODS: </B>All patients who underwent reconstruction after full-thickness chest wall resection from 2000 to 2022 were reviewed and stratified by prosthesis type (biologic or synthetic). Biologic prostheses were of biologic origin or were fully absorbable and incorporable. Integer matching was performed to reduce confounding. The study end point was surgical site complications requiring reoperation. Multivariable analysis was performed to identify associated risk factors.<BR><B>RESULTS: </B>In total, 438 patients underwent prosthetic chest wall reconstruction (unmatched: biologic, n = 49; synthetic, n = 389; matched: biologic, n = 46; synthetic, n = 46). After matching, the median (interquartile range) defect size was 83 cm2 (50-142) for the biologic group and 90 cm2 (48-146) for the synthetic group (P = 0.97). Myocutaneous flaps were used in 33% of biologic reconstructions (n = 15) and 33% of synthetic reconstructions (n = 15) in the matched cohort (P = 0.99). The incidence of surgical site complications requiring reoperation was not significantly different between biologic and synthetic reconstructions in the unmatched (3 [6%] vs 29 [7%]; P = 0.99) and matched (2 [4%] vs 4 [9%]; P = 0.68) cohorts. On the multivariable analysis, operative time [adjusted odds ratio (aOR) = 1.01, 95% confidence interval (CI), 1.00-1.01; P = 0.006] and operative blood loss (aOR = 1.00, 95% CI, 1.00-1.00]; P = 0.012) were associated with higher rates of surgical site complications requiring reoperation; microvascular free flaps (aOR = 0.03, 95% CI, 0.00-0.42; P = 0.024) were associated with lower rates.<BR><B>CONCLUSIONS: </B>The incidence of surgical site complications requiring reoperation was not significantly different between biologic and synthetic prostheses in chest wall reconstructions.