%0 Journal Article
%T Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon.
%A Micali N
%A Ma S
%A Li M
%A Kim SK
%A Mato-Blanco X
%A Sindhu SK
%A Arellano JI
%A Gao T
%A Shibata M
%A Gobeske KT
%A Duque A
%A Santpere G
%A Sestan N
%A Rakic P
%J Science
%V 382
%N 6667
%D 2023 10 13
%M 37824652
%F 63.714
%R 10.1126/science.adf3786
%X During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding of these processes in primates, including both conserved and species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We deciphered the molecular programs of the early organizing centers and their cross-talk with NSCs, revealing primate-biased galanin-like peptide (GALP) signaling in the anteroventral telencephalon. Regional transcriptomic variations were observed along the frontotemporal axis during early stages of neocortical NSC progression and in neurons and astrocytes. Additionally, we found that genes associated with neuropsychiatric disorders and brain cancer risk might play critical roles in the early telencephalic organizers and during NSC progression.