%0 Journal Article
%T Establishment of tongue microbiota by 18 months of age and determinants of its microbial profile.
%A Kageyama S
%A Ma J
%A Furuta M
%A Takeshita T
%A Asakawa M
%A Okabe Y
%A Yamashita Y
%J mBio
%V 14
%N 5
%D 2023 Oct 31
%M 37819142
暂无%R 10.1128/mbio.01337-23
%X <B>OBJECTIVE: </B>Understanding the development of oral microbiota early in life and the factors that influence it is important for preventing the establishment of dysbiotic oral microbiota later in life. This study demonstrates that the tongue microbiota undergoes early development from 4 to 18 months of age and converges into two types of microbiota showing indications of adult characteristics, with either S. salivarius or Neisseria-dominance. Interestingly, their divergence was strongly determined by their weaning status and the dietary frequencies of sweetened beverages, snacks, and fruits, suggesting that dietary habits during this period might influence the establishment of the oral microbiota. These findings may contribute to the development of novel preventive strategies against oral microbiota-related diseases.