%0 Case Reports %T Large mesenchymal cystic and chondroid pulmonary hamartoma mimicking lung cancer: Case report. %A Ahn S %A Lee H %A Kang JK %A Kim IS %A Moon Y %A Choi JS %A Choi SY %J J Cardiothorac Surg %V 18 %N 1 %D 2023 Oct 10 %M 37817244 %F 1.522 %R 10.1186/s13019-023-02394-z %X Pulmonary hamartoma is the most commonly resected benign neoplasm of lung. The mesenchymal cystic subtype is a rare and often bilaterally occurring variant composed of multiple cysts and nodules. Herein, we present an asymptomatic 70-year-old woman with a large and mostly cystic growth of right hilar region. Computed tomography of the chest and fluorodeoxyglucose positron emission tomography/computed tomography imaging traced its origins to right middle lobe. Overall features suggested primary lung cancer or perhaps other cystic lung disease.Because transbronchial lung biopsy failed to establish a histologic diagnosis, right middle lobectomy was undertaken by video-assisted thoracoscopic surgery. The gross surgical specimen harbored a single and sizeable (8.0 × 4.0 cm) cystic lesion containing multiple yellow-white nodules. A diagnosis of mesenchymal cystic and chondroid hamartoma was ultimately rendered. This particular case is noteworthy, given the initial clinical resemblance to primary lung cancer.