%0 Journal Article
%T Anthropometric measures, predicted visceral adipose tissue and biomarkers of chronic inflammation.
%A Millar SR
%A Perry IJ
%A Phillips CM
%J Eur J Clin Invest
%V 54
%N 2
%D 2024 Feb 9
%M 37814451
%F 5.722
%R 10.1111/eci.14104
%X <B>BACKGROUND: </B>Evidence has linked low-grade systemic inflammation and visceral adipose tissue (VAT) with development of chronic conditions. Cytokines and select proteins released by VAT may promote a low-grade inflammatory response. A number of equations have been developed to estimate VAT levels. In this study, we compared predicted VAT equation relationships with biomarkers of inflammation.<BR><B>METHODS: </B>This was a cross-sectional study of 2038 men and women aged 46-73 years. Correlation and linear regression analyses were performed to examine inflammatory biomarker relationships with four commonly assessed anthropometric measures and 10 predicted VAT equations.<BR><B>RESULTS: </B>Compared with anthropometric measures, predicted VAT equations were found to explain a greater proportion of variance in CRP (R2  = .075, p = .001), IL-6 (R2  = .060, p = .001), TNF-α (R2  = .017, p = .005), resistin (R2  = .011, p = .012), monocyte (R2  = .027, p = .001), eosinophil (R2  = .012, p = .01) and basophil (R2  = .015, p = .002) levels in males, and a greater variance in concentrations of C3 (R2  = .175, p = .001), IL-6 (R2  = .090, p = .001), TNF-α (R2  = .036, p = .001), adiponectin (R2  = .121, p = .001), the adiponectin-to-leptin ratio (R2  = .444, p = .001), resistin (R2  = .025, p = .001), white blood cell count (R2  = .057, p = .001), neutrophils (R2  = .061, p = .001) and lymphocytes (R2  = .020, p = .001) in females.<BR><B>CONCLUSIONS: </B>Equations for assessing VAT levels might be useful to characterise metabolic health. Further studies that examine predicted VAT relationships with disease and mortality outcomes are warranted.