%0 Meta-Analysis
%T A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe.
%A Hassoun-Kheir N
%A Guedes M
%A Ngo Nsoga MT
%A Argante L
%A Arieti F
%A Gladstone BP
%A Kingston R
%A Naylor NR
%A Pezzani MD
%A Pouwels KB
%A Robotham JV
%A Rodríguez-Baño J
%A Tacconelli E
%A Vella V
%A Harbarth S
%A de Kraker MEA
%A
%J Clin Microbiol Infect
%V 30
%N 0
%D 2024 Mar
%M 37802750
%F 13.31
%R 10.1016/j.cmi.2023.09.001
%X BACKGROUND: Antimicrobial resistance is a global threat, which requires novel intervention strategies, for which priority pathogens and settings need to be determined.
OBJECTIVE: We evaluated pathogen-specific excess health burden of drug-resistant bloodstream infections (BSIs) in Europe.
METHODS: A systematic review and meta-analysis.
METHODS: MEDLINE, Embase, and grey literature for the period January 1990 to May 2022.
METHODS: Studies that reported burden data for six key drug-resistant pathogens: carbapenem-resistant (CR) Pseudomonas aeruginosa and Acinetobacter baumannii, third-generation cephalosporin or CR Escherichia coli and Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium. Excess health outcomes compared with drug-susceptible BSIs or uninfected patients. For MRSA and third-generation cephalosporin E. coli and K. pneumoniae BSIs, five or more European studies were identified. For all others, the search was extended to high-income countries.
METHODS: Paediatric and adult patients diagnosed with drug-resistant BSI.
METHODS: Not applicable.
UNASSIGNED: An adapted version of the Joanna-Briggs Institute assessment tool.
UNASSIGNED: Random-effect models were used to pool pathogen-specific burden estimates.
RESULTS: We screened 7154 titles, 1078 full-texts and found 56 studies on BSIs. Most studies compared outcomes of drug-resistant to drug-susceptible BSIs (46/56, 82.1%), and reported mortality (55/56 studies, 98.6%). The pooled crude estimate for excess all-cause mortality of drug-resistant versus drug-susceptible BSIs ranged from OR 1.31 (95% CI 1.03-1.68) for CR P. aeruginosa to OR 3.44 (95% CI 1.62-7.32) for CR K. pneumoniae. Pooled crude estimates comparing mortality to uninfected patients were available for vancomycin-resistant Enterococcus and MRSA BSIs (OR of 11.19 [95% CI 6.92-18.09] and OR 6.18 [95% CI 2.10-18.17], respectively).
CONCLUSIONS: Drug-resistant BSIs are associated with increased mortality, with the magnitude of the effect influenced by pathogen type and comparator. Future research should address crucial knowledge gaps in pathogen- and infection-specific burdens to guide development of novel interventions.