%0 Case Reports
%T Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report.
%A Xie J
%A Li Z
%A Jiang Y
%A Tang D
%A Qiu X
%A Jia E
%A Zhang J
%J Front Pharmacol
%V 14
%N 0
%D 2023
%M 37767406
%F 5.988
%R 10.3389/fphar.2023.1191158
%X Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued to progress; the patient responded well to baricitinib. This suggests that JAK/STAT signaling pathways play an essential role in the pathological process of POEMS syndrome.