%0 Case Reports
%T A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV.
%A De Benedetto I
%A Biagini F
%A Urbano G
%A Mongini TE
%A Cassetta I
%A Scaglione L
%A Curtoni A
%A Calleri G
%A Calcagno A
%A De Rosa FG
%A Corcione S
%J Infez Med
%V 31
%N 3
%D 2023
%M 37701394
暂无%R 10.53854/liim-3103-16
%X We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.