%0 Journal Article
%T Daily fosfomycin versus levofloxacin for complicated urinary tract infections.
%A Rouphael N
%A Winokur P
%A Keefer MC
%A Traenkner J
%A Drobeniuc A
%A Doi Y
%A Munsiff S
%A Fowler VG
%A Evans S
%A Oler RE
%A Tuyishimire B
%A Lee M
%A Ghazaryan V
%A Chambers HF
%A  
%J mBio
%V 14
%N 5
%D 2023 Oct 31
%M 37698412
暂无%R 10.1128/mbio.01677-23
%X <B>OBJECTIVE: </B>Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.