%0 Journal Article
%T Pancreatic cancer near the splenic hilum has a higher likelihood of splenic vessel invasion and unfavorable survival.
%A Ueda H
%A Takahashi H
%A Kobayashi S
%A Sasaki K
%A Iwagami Y
%A Yamada D
%A Tomimaru Y
%A Asaoka T
%A Noda T
%A Tanemura M
%A Doki Y
%A Eguchi H
%J Langenbecks Arch Surg
%V 408
%N 1
%D 2023 Sep 11
%M 37695403
%F 2.895
%R 10.1007/s00423-023-03089-8
%X <B>OBJECTIVE: </B>This study aimed to investigate whether clinical outcomes varied based on the tumor location within the pancreatic body and tail in patients with pancreatic cancer (PC).<BR><B>METHODS: </B>Ninety-five patients who had undergone a distal pancreatectomy for resectable (R) or borderline resectable (BR) PC within the pancreatic body or tail region were retrospectively investigated and divided into four groups (three subgroups of R-PC according to tumor location, and BR-PC): R-PC in the pancreatic body region (group A, n = 24), R-PC on the right side of the pancreatic tail region (group B, n = 17), R-PC on the left side of the pancreatic tail region (group C, n = 29), and BR-PC located in any region within the pancreatic body and tail (group BR, n = 25).<BR><B>RESULTS: </B>Group C patients showed a higher incidence of pretreatment splenic artery and vein involvement than group A and B patients (splenic artery: 8.3/11.8/41.4%, p < 0.010; splenic vein: 25.0/23.5/79.3%, p < 0.010, in groups A/B/C, respectively). The overall survival of group C patients was significantly unfavorable compared to that of group A and B patients (median: 3.9/4.2/2.3 years in groups A/B/C, p = 0.029, respectively). Pretreatment clinical factors were comparable between group C and group BR. Median survival rates were comparable between group C and BR patients (2.3 and 2.0 years, respectively) (p = 0.93).<BR><B>CONCLUSIONS: </B>Differences in anatomical location within the pancreatic body and tail characterize the unfavorable outcomes of PC near the splenic hilum.