%0 Journal Article
%T A review on therapeutic mechanism of medicinal plants against osteoporosis: effects of phytoconstituents.
%A Kumari S
%A Singh M
%A Nupur 
%A Jain S
%A Verma N
%A Malik S
%A Rustagi S
%A Priya K
%J Mol Biol Rep
%V 50
%N 11
%D 2023 Nov 7
%M 37676432
%F 2.742
%R 10.1007/s11033-023-08751-4
%X Osteoporosis is a metabolic bone disorder that over time results in bone loss and raises the risk of fracture. The condition is frequently silent and only becomes apparent when fractures develop. Osteoporosis is treated with pharmacotherapy as well as non-pharmacological therapies such as mineral supplements, lifestyle changes, and exercise routines. Herbal medicine is frequently used in clinical procedures because of its low risk of adverse effects and cost-effective therapeutic results. In the current review, we have used a thorough strategy to identify some known medicinal plants with anti-osteoporosis capabilities, their origin, active ingredients, and pharmacological information. Furthermore, several signaling pathways, such as the apoptotic pathway, transcription factors, the Wnt/-catenin signaling pathway, and others, are regulated by bioactive components and help to improve bone homeostasis. This review will provide a better understanding of the anti-osteoporotic effects of bioactive components and the concomitant modulations of signaling pathways.