%0 Journal Article
%T Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice.
%A Cai Z
%A Zeng Y
%A Liu Z
%A Zhu R
%A Wang W
%J Clin Cosmet Investig Dermatol
%V 16
%N 0
%D 2023
%M 37675183
%F 2.765
%R 10.2147/CCID.S423922
%X <B>UNASSIGNED: </B>To further investigate why curcumin (CUR) can attenuate psoriasis-like dermatitis of mice.<BR><B>UNASSIGNED: </B>Sixteen mice were randomized into four groups. The control group used carrier cream, and the model and the CUR group were applied with topical 5% imiquimod in the naked mice skin once a day for 6 days (62.5 mg/day/mice). Meanwhile, the control and model mice were given the same dose of saline by oral means, while mice in the CUR groups received oral drug doses of 50 and 100 mg/kg once a day for 6 days, respectively. CUR could largely improve imiquimod-induced lesions of mice. By using the ELISA and qPCR, we found that the protein and mRNA levels of epidermal TNF-α and IL-6 were inhibited by CUR. The phosphorylation levels of STAT3 and its downstream associated protein levels (eg, Cyclin D1, Bcl-2 and Pim1) in skin tissues of different groups were also inhibited by CUR. Furthermore, the results of immunohistochemistry also showed the repressed effect of CUR for the expression of TNF-α, IL-6 and p-STAT3 in psoriasis-like lesions of mice.<BR><B>UNASSIGNED: </B>CUR can effectively ameliorate the featured lesions of psoriasis mice, which may be closely associated with the involvement of IL-6/STAT3 signaling.