%0 Journal Article
%T Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice.
%A Curlin JZ
%A Schmitt K
%A Remling-Mulder L
%A Tibbitts CV
%A O'Connor S
%A Marx P
%A Akkina R
%J J Med Primatol
%V 52
%N 5
%D 2023 10 1
%M 37658595
%F 0.821
%R 10.1111/jmp.12675
%X HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.