%0 Journal Article
%T A Multicenter Retrospective Cohort Study on Management Protocols and Clinical Outcomes After ABO-incompatible Kidney Transplantation in India.
%A Kute VB
%A Pathak V
%A Ray DS
%A Bhalla AK
%A Godara SM
%A Narayanan S
%A Hegde U
%A Das P
%A Jha PK
%A Kher V
%A Dalal S
%A Bahadur MM
%A Gang S
%A Sinha VK
%A Patel HV
%A Deshpande R
%A Mali M
%A Sharma A
%A Das SS
%A Thukral S
%A Shingare A
%A Bt AK
%A Hafeeq B
%A Aziz F
%A Aboobacker IN
%A Gopinathan JC
%A Dave RM
%A Bansal D
%A Anandh U
%A Singh S
%A Kriplani J
%A Bavikar S
%A Siddini V
%A Balan S
%A Singla M
%A Chauhan M
%A Tripathi V
%A Patwari D
%A Abraham AM
%A Chauhan S
%A Meshram HS
%J Transplantation
%V 108
%N 2
%D 2024 Feb 1
%M 37641175
%F 5.385
%R 10.1097/TP.0000000000004789
%X <B>BACKGROUND: </B>There is no robust evidence-based data for ABO-incompatible kidney transplantation (ABOiKT) from emerging countries.<BR><B>METHODS: </B>Data from 1759 living donor ABOiKT and 33 157 ABO-compatible kidney transplantations (ABOcKT) performed in India between March 5, 2011, and July 2, 2022, were included in this retrospective, multicenter (n = 25) study. The primary outcomes included management protocols, mortality, graft loss, and biopsy-proven acute rejection (BPAR).<BR><B>RESULTS: </B>Protocol included rituximab 100 (232 [13.18%]), 200 (877 [49.85%]), and 500 mg (569 [32.34%]); immunoadsorption (IA) (145 [8.24%]), IVIG (663 [37.69%]), and no induction 200 (11.37%). Mortality, graft loss, and BPAR were reported in 167 (9.49%), 136 (7.73%), and 228 (12.96%) patients, respectively, over a median follow-up of 36.3 mo. In cox proportional hazard model, mortality was higher with IA (hazard ratio [HR]: 2.53 [1.62-3.97]; P  < 0.001), BPAR (HR: 1.83 [1.25-2.69]; P  = 0.0020), and graft loss (HR: 1.66 [1.05-2.64]; P  = 0.0310); improved graft survival was associated with IVIG (HR: 0.44 [0.26-0.72]; P  = 0.0010); higher BPAR was reported with conventional tube method (HR: 3.22 [1.9-5.46]; P  < 0.0001) and IA use (HR: 2 [1.37-2.92]; P  < 0.0001), whereas lower BPAR was reported in the prepandemic era (HR: 0.61 [0.43-0.88]; P  = 0.008). Primary outcomes were not associated with rituximab dosing or high preconditioning/presurgery anti-A/anti-B titers. Incidence of overall infection 306 (17.39%), cytomegalovirus 66 (3.75%), and BK virus polyoma virus 20 (1.13%) was low. In unmatched univariate analysis, the outcomes between ABOiKT and ABOcKT were comparable.<BR><B>CONCLUSIONS: </B>Our largest multicenter study on ABOiKT provides insights into various protocols and management strategies with results comparable to those of ABOcKT.