%0 Journal Article
%T Pyroglutamic Acidosis - An Underrecognised Entity Associated with Acetaminophen Use.
%A Ng WW
%A Tong HF
%A Ng WY
%A Yeung JK
%A Young JK
%A Woo RK
%A Wong MM
%J Rom J Anaesth Intensive Care
%V 30
%N 1
%D 2023 Apr
%M 37635852
暂无%R 10.2478/rjaic-2023-0004
%X Pyroglutamic acidosis (PGA) is an underrecognized entity characterised by raised anion gap metabolic acidosis (RAGMA) and urinary hyper-excretion of pyroglutamic acid. It is frequently associated with chronic acetaminophen (APAP) ingestion. We report the case of a 73-year-old man with invasive pulmonary aspergillosis treated with voriconazole and APAP for analgesia with a cumulative dose of 160 g over 40 days. PGA was suspected as he developed severe RAGMA and common causes were excluded. Diagnosis was confirmed via urinary organic acid analysis which showed significant hyper-excretion of pyroglutamic acid. APAP was discontinued, and N-acetylcysteine (NAC) was administered. His RAGMA rapidly resolved following treatment.