%0 Case Reports
%T Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11.
%A Gao W
%A Li W
%A Zheng Q
%A Jiang N
%A Tang H
%J Front Public Health
%V 11
%N 0
%D 2023
%M 37601204
%F 6.461
%R 10.3389/fpubh.2023.1217662
%X We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11.<BR>A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%-6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes.<BR>Hb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion.