%0 Journal Article
%T Abnormal acinar-β-cell crosstalk in type 2 diabetes.
%A Geravandi S
%A Ardestani A
%J Trends Endocrinol Metab
%V 34
%N 11
%D 2023 Nov 18
%M 37599202
%F 10.586
%R 10.1016/j.tem.2023.08.006
%X Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific pancreatic elastase CELA3B within endocrine islets reduces β-cell viability in type 2 diabetes (T2D). This identifies detrimental acinar-β-cell crosstalk as a novel pathogenic mechanism in diabetes.