%0 Journal Article
%T Association of Proliferative Indices With Various Grades of Breast Carcinoma.
%A Awasthi S
%A Gupta P
%A Mittal A
%J Cureus
%V 15
%N 7
%D 2023 Jul
%M 37583729
暂无%R 10.7759/cureus.41865
%X <B>OBJECTIVE: </B>Various grades of breast carcinoma and proliferative indices used as nuclear protein Ki-67 and argyrophilic nucleolar organizer regions (AgNOR) are being compared to each other.<BR><B>METHODS: </B>In this observational cross-sectional investigation, 42 breast biopsies from questionable breast areas were collected and preserved in formalin and paraffin before the tissue blocks were made. A thorough medical history regarding the breast tumor and thorough physical examination results were recorded. Two sections were produced, one stained with an immunohistochemical marker called Ki-67 and the other with a unique stain called AgNOR.<BR><B>RESULTS: </B>Grade I in Nottingham was found to be highest in subjects with Ki-67 1%, grade II in subjects with Ki-67 1-10%, and grade III in subjects with Ki-67>10%. Therefore, a higher Ki-67 score and a higher Nottingham grade were more closely associated. The mean AgNOR score was determined to be highest in Nottingham grade III and lowest in Nottingham grade I. In contrast to grade I and grade II of carcinoma (CA) breast, where there was no statistically significant association between Ki-67 and AgNOR, grade III of CA breast showed a statistically significant link between Ki-67 and AgNOR.<BR><B>CONCLUSIONS: </B>Proliferation has been identified as a distinctive feature of cancer and as a key factor in the prognosis of the disease.