%0 Case Reports %T Clearance of Mycoplasma ovipneumoniae in Captive Bighorn Sheep (Ovis canadensis) Following Extended Oral Doxycycline Treatment. %A Wood ME %A Edwards WH %A Jennings-Gaines JE %A Gaston M %A Van Wick P %A Amundson S %A Allen SE %A Wolfe LL %J J Wildl Dis %V 59 %N 4 %D 2023 10 1 %M 37578752 %F 1.626 %R 10.7589/JWD-D-22-00094 %X Respiratory disease is a significant barrier for bighorn sheep (Ovis canadensis) conservation, and a need remains for management options in both captive and free-ranging populations. We treated Mycoplasma ovipneumoniae infection in six bighorn lambs and five bighorn yearlings at two captive research facilities with twice daily oral doxycycline for 8 wk or longer. Doses of 5 mg/kg twice daily mixed in formula for lambs and 10 mg/kg twice daily mixed in moistened pellets for older lambs and yearlings were tolerated well with minimal side effects. All animals in this case report remain Mycoplasma ovipneumoniae free over 2 yr later. Further evaluation is warranted to confirm efficacy of this therapeutic approach.