%0 Journal Article
%T The association of serum C-peptide with the risk of cardiovascular events: a meta-analysis and systematic review.
%A Jahromi MK
%A Ahmadirad H
%A Jamshidi S
%A Farhadnejad H
%A Mokhtari E
%A Shahrokhtabar T
%A Tavakkoli S
%A Teymoori F
%A Mirmiran P
%J Diabetol Metab Syndr
%V 15
%N 1
%D 2023 Aug 11
%M 37568168
%F 5.395
%R 10.1186/s13098-023-01142-6
%X <B>BACKGROUND: </B>C-peptide is considered a peptide with active function in the body, which can affect people's health. However, the results of previous studies on the possible association of C-peptide with the risk of cardiometabolic disorders have not been fully understood. This systematic review and meta-analysis aimed to investigate the association between serum C-peptide level and the risk of cardiovascular disease (CVD) events.<BR><B>METHODS: </B>The various important databases, including PubMed, Scopus, and Web of Science, were searched comprehensively to November 2022 to identify the relevant studies. The HR(95% CI) or OR(95% CI) for observational studies were extracted and converted into log HR or log OR and their standard deviation(SD) was computed. A random-effects model with an inverse variance weighting method was conducted, to calculate the pooled effect size.<BR><B>RESULTS: </B>Sixteen observational studies, including one case-control study, eight cohort studies, and seven cross-sectional studies were included in the current meta-analysis. The sample size ranged from 90 to 7030, with an age range from 12 to 85 years. During the follow-up time (ranging from 5 to 17 years), 4852 CVD events occurred. Based on cohort and case-control studies, the pooled results showed no significant association between serum C-peptide with CVD events risk (RR = 1.02;95%CI:0.91-1.15, I2 = 34.7%; P-heterogeneity = 0.140). For cross-sectional studies, the pooled results indicated a positive association between serum C-peptide and the odds of CVD outcomes (OR = 1.35;95%CI:1.04-1.76, I2 = 83.6%; P-heterogeneity < 0.001).<BR><B>CONCLUSIONS: </B>The pooled results of the current study suggested that C-peptide level was not related to the risk of CVD events in cohort studies, however, the meta-analysis of cross-sectional studies showed a significant association between C-peptide and an increased risk of CVD events.